Landscape Design Dialogue. Bridging the gap between knowledge and action

Spatial planners and landscape architects do not excel in theory development. The authors, being a practicing landscape architect-planner and a planning scholar, explore new roads to a middle range theory of landscape design and planning. Building on theories-in-use in regional planning practice they develop an empirically grounded methodology for planning and design. The process of theory building is part of a process of methodical reflection on best and worst practices. It focuses on an analysis of planning and design efforts in the period 1970 – 2005 which have gradually transformed the landscape of the Rhine-Meuse Flood Plain in the Netherland

Voedsel en ruimtelijke planning : een verkenning

Het doel van deze studie is hiermee enerzijds om te verkennen wat de planning van het voedselsysteem zou kunnen inhouden en welke bijdrage ruimtelijke planning hieraan kan leveren. Anderzijds wordt verkend wat onder ruimtelijke planning wordt verstaan en welke bijdrage de planning van het voedselsysteem hieraan kan leveren

The Cultural Landscape & Heritage Paradox; Protection and Development of the Dutch Archeological-Historical Landscape and its European Dimension

To what extent can we know past and mainly invisible landscapes, and how we can use this still hidden knowledge for actual sustainable management of landscape’s cultural and historical values. It has also been acknowledged that heritage management is increasingly about ‘the management of future change rather than simply protection’. This presents us with a paradox: to preserve our historic environment, we have to collaborate with those who wish to transform it and, in order to apply our expert knowledge, we have to make it suitable for policy and society. The answer presented by the Protection and Development of the Dutch Archaeological-Historical Landscape programme (pdl/bbo) is an integrative landscape approach which applies inter- and transdisciplinarity, establishing links between archaeological-historical heritage and planning, and between research and policy. This is supported by two unifying concepts: ‘biography of landscape’ and ‘action research’. This approach focuses upon the interaction between knowledge, policy and an imagination centered on the public. The European perspective makes us aware of the resourcefulness of the diversity of landscapes, of social and institutional structures, of various sorts of problems, approaches and ways forward. In addition, two related issues stand out: the management of knowledge creation for landscape research and management, and the prospects for the near future. Underlying them is the imperative that we learn from the past ‘through landscape’

Interdisciplinarity and transdisciplinarity in landscape studies - the Wageningen DELTA approach

Explanation of the Dutch approach of landscape research, planning and managemen

Naar de Hof van Delfland

De commissie heeft, in overleg met de bestuurlijke trekkers en Riek Bakker, de vrijheid genomen om het werkgebied ruimer op te vatten dan de gebiedsafbakening van de opdrachtgever. Het advies heeft betrekking op het cultuurlandschap en het groen in het gebied tussen de glastuinbouw van het Westland, en de aaneengesloten stedelijke bebouwing van Den Haag, Rotterdam en Zoetermeer. Daaronder wordt dus uitdrukkelijk begrepen de Groenzone Berkel-Pijnacker. De commissie stelt zich op het standpunt dat de cultuurhistorische en ecologische waarden van het kerngebied in stand moeten worden gehouden en versterkt. Versterking kan gebeuren door het beter zichtbaar en beleefbaar maken van de aanwezige waarden voor bezoekers uit de omliggende steden. De commissie brengt dus een territoriale driedeling aan in haar werkgebied. - Het kerngebied. Dit is het gebied onder de werking van de aflopende Reconstructiewet Midden-Delfland, aangevuld met Oude Leede en Ackerdijkse Plassen. - De stadsranden. Hier is ruimte voor passende ontwikkelingen zoals recreatievoorzieningen, passende sociale functies, groen wonen, ecologische en cultuurhistorische verbindingszones, en andere infrastructuur. - De uitlopers. Hier moeten mogelijkheden worden gezocht voor ontwikkelingen die de kwaliteit van het metropolitane landschap als geheel versterke

Immunogenicity and reactogenicity of SARS-CoV-2 vaccines in people living with HIV in the Netherlands: a nationwide prospective cohort study

Background: Vaccines can be less immunogenic in people living with HIV (PLWH), but for SARS-CoV-2 vaccinations this is unknown. In this study we set out to investigate, for the vaccines currently approved in the Netherlands, the immunogenicity and reactogenicity of SARS-CoV-2 vaccinations in PLWH. Methods and findings: We conducted a prospective cohort study to examine the immunogenicity of BNT162b2, mRNA-1273, ChAdOx1-S, and Ad26.COV2.S vaccines in adult PLWH without prior COVID-19, and compared to HIV-negative controls. The primary endpoint was the anti-spike SARS-CoV-2 IgG response after mRNA vaccination. Secondary endpoints included the serological response after vector vaccination, anti-SARS-CoV-2 T-cell response, and reactogenicity. Between 14 February and 7 September 2021, 1,154 PLWH (median age 53 [IQR 44-60] years, 85.5% male) and 440 controls (median age 43 [IQR 33-53] years, 28.6% male) were included in the final analysis. Of the PLWH, 884 received BNT162b2, 100 received mRNA-1273, 150 received ChAdOx1-S, and 20 received Ad26.COV2.S. In the group of PLWH, 99% were on antiretroviral therapy, 97.7% were virally suppressed, and the median CD4+ T-cell count was 710 cells/mu L (IQR 520-913). Of the controls, 247 received mRNA-1273, 94 received BNT162b2, 26 received ChAdOx1-S, and 73 received Ad26.COV2.S. After mRNA vaccination, geometric mean antibody concentration was 1,418 BAU/mL in PLWH (95% CI 1322-1523), and after adjustment for age, sex, and vaccine type, HIV status remained associated with a decreased response (0.607, 95% CI 0.5080.725, p 300 BAU/mL, whilst in PLWH this response rate was 93.6%. In PLWH vaccinated with mRNA-based vaccines, higher antibody responses were predicted by CD4+ Tcell count 250-500 cells/mu L (2.845, 95% CI 1.876-4.314, p 500 cells/mu L (2.936, 95% CI 1.961-4.394, p 50 copies/mL was associated with a reduced response (0.454, 95% CI 0.286-0.720, p = 0.001). Increased IFN-gamma, CD4+ T-cell, and CD8+ T-cell responses were observed after stimulation with SARS-CoV-2 spike peptides in ELISpot and activation-induced marker assays, comparable to controls. Reactogenicity was generally mild, without vaccine-related serious adverse events. Due to the control of vaccine provision by the Dutch National Institute for Public Health and the Environment, there were some differences between vaccine groups in the age, sex, and CD4+ Tcell counts of recipients.Conclusions: After vaccination with BNT162b2 or mRNA-1273, anti-spike SARS-CoV-2 antibody levels were reduced in PLWH compared to HIV-negative controls. To reach and maintain the same serological responses as HIV-negative controls, additional vaccinations are probably required. Author summary: Why was this study done? The efficacy of SARS-CoV-2 vaccines in people living with HIV (PLWH) is not well characterised.HIV has been repeatedly associated with lower immune responses to other vaccines, and this diminished response is strongly correlated with CD4+ T-cell count.The SARS-CoV-2 vaccines BNT162b2, mRNA-1273, ChAdOx1-S, and Ad26.COV2.S showed good protection against severe COVID-19 and hospitalisation in phase III registration trials; however, the number of PLWH in these trials was very limited. What did the researchers do and find?We initiated a nationwide prospective study including 1,154 PLWH and 440 HIV-negative controls.We show that lower antibody levels are seen in PLWH compared to controls after completion of the vaccination schedule, regardless of the vaccine received.All controls receiving an mRNA vaccine had an adequate response, defined as >300 BAU/mL, whilst in PLWH this response rate was 93.6%. In multivariable analyses, having HIV had the largest negative effect on antibody responses following vaccination, more than both age and sex. Following mRNA vaccination, the antibody response was higher in PLWH with CD4+ T-cell counts between 250 and 500 cells/mu L or higher than 500 cells/mu L (both p Immunogenetics and cellular immunology of bacterial infectious disease